COUNTY · SC
Cherokee County, South Carolina
Cherokee County is a county in South Carolina with FIPS code 45021 and an estimated population of 56,714 (Census 2023), 24th largest of 46 in the state.
County facts
- Name
- Cherokee County
- State
- South Carolina
- Type
- county
- FIPS code
- 45021
- State FIPS
- 45
- Population (2023)
- 56,714
- Change since 2020
- +0.9%
- State rank
- 24 of 46
Population is the Census Bureau’s Vintage 2023 estimate.
Other counties in South Carolina
Questions
What is the FIPS code for Cherokee County?
Cherokee County, South Carolina has the five-digit FIPS code 45021: 45 for the state and 021 for the county.
What state is Cherokee County in?
Cherokee County is in South Carolina.
How do I know if an address is in this county?
Use the address lookup. ZIP codes and city names can cross county lines, so an address is the reliable check.
Sources: U.S. Census Bureau geographic reference files; Census Bureau Population Estimates, Vintage 2023. Last reviewed 2026-10-27.